منابع مشابه
Involvement of Rho-kinase in TGF-β-stimulated heat shock protein 27 induction in osteoblasts.
We previously reported that transforming growth factor-β (TGF-β) stimulates heat shock protein 27 (HSP27) induction through p44/p42 mitogen-activated protein (MAP) kinase, p38 MAP kinase and stress-activated protein kinase/ c-Jun N-terminal kinase (SAPK/JNK) in osteoblast-like MC3T3-E1 cells. In addition, we recently reported that the Rho-kinase inhibitors Y27632 and fasudil suppressed the TGF-...
متن کاملEndothelin-1 stimulates heat shock protein 27 induction in osteoblasts: involvement of p38 MAP kinase.
We previously reported that endothelin-1 (ET-1) activates p42/p44 mitogen-activated protein (MAP) kinase in osteoblast-like MC3T3-E1 cells and consequently induces synthesis of interleukin-6. In the present study, we investigated the effect of ET-1 on the induction of heat shock protein 27 (HSP 27) in MC3T3-E1 cells. ET-1 time and dose dependently stimulated HSP 27 accumulation. ET-1 induced an...
متن کاملHeat shock protein 27 (HSPB1) suppresses the PDGF-BB-induced migration of osteoblasts
Heat shock protein 27 (HSP27/HSPB1), one of the small heat shock proteins, is constitutively expressed in various tissues. HSP27 and its phosphorylation state participate in the regulation of multiple physiological and pathophysiological cell functions. However, the exact roles of HSP27 in osteoblasts remain unclear. In the present study, we investigated the role of HSP27 in the platelet-derive...
متن کاملUnphosphorylated heat shock protein 27 suppresses fibroblast growth factor‑2‑stimulated vascular endothelial growth factor release in osteoblasts.
Heat shock protein 27 (HSP27) also known as heat shock protein β1 (HSPB1) is a member of the family of small heat shock proteins ubiquitously expressed in all tissues. It has previously been demonstrated that HSP27 regulated the synthesis of osteocalcin and interleukin‑6 in osteoblast‑like MC3T3‑E1 cells. In the present study, the effect of HSP27 on basic fibroblast growth factor (FGF‑2)‑stimul...
متن کاملHyperglycemia and antibody titres against heat shock protein 27 in traumatic brain injury patients on parenteral nutrition
Objective(s):Hyperglycemia worsens the neuronal death induced by cerebral ischemia. Previous studies demonstrated that diabetic hyperglycemia suppressed the expression of heat shock protein 70 and 60 (HSP70 and 60) in the liver. IgG antibody titres against heat shock protein 27 (anti HSP27) were measured to determine whether hyperglycemia exacerbates ischemic brain damage by suppressing the exp...
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ژورنال
عنوان ژورنال: Folia Pharmacologica Japonica
سال: 2002
ISSN: 0015-5691,1347-8397
DOI: 10.1254/fpj.119.89